Direct ligand binding triggers a conformational change in the receptor allowing it to recruit co regulators and initiate transcription.
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The effect of nitric acid on aerosol particles in the atmosphere may offer an explanation for the.
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4 their ligands include metabolites vitamins and hormones as well as xenobiotics.
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We know little about the best way to get to a diagnosis and about what prognoses are implied let alone what treatment works best in specific situations.
Clozapine has a complex hepatic metabolism in man with multiple cyp isoforms being involved in its biotransformation.
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Nuclear receptors comprise one of the largest groups of transcription factors found in humans consisting of 48 different members.
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The major metabolic pathways are the n demethylation and the n oxidation to form norclozapine which has limited pharmacological activity and clozapine n oxide respectively 24 26 27 currently available in vitro and in vivo evidence clearly indicate that cyp1a2 plays.