Mini Stem Cell Transplant For Myelofibrosis

Some mf patients present to the transplant center with severe complications after a long disease history and their treatment may be very challenging.

Mini stem cell transplant for myelofibrosis.

My sister was only a 50 match. The patient is given chemotherapy or radiation therapy in order to remove defective bone marrow. It is beneficial to improve the outcomes of this procedure in myelofibrosis. Myelofibrosis is a rare kind of blood cancer that keeps your body from making the blood cells you need to be healthy.

Hematopoietic cell transplantation as curative therapy for idiopathic myelofibrosis advanced polycythemia vera and essential thrombocythemia. Allogeneic stem cell transplantation for myelofibrosis in 2012 donal p. It is usually risky for older patients and those individuals with other health problems. Myelofibrosis is typically treated with a stem cell transplant so i started working with uday popat m d to find a donor.

And because of the variable outcome of patients with myelofibrosis treatment decision with. A bone marrow aspiration revealed i d developed myelofibrosis a type of bone cancer. Treating my myelofibrosis with a stem cell transplant. A reduced intensity non myeloablative or mini transplant is a conditioning process in which lower doses of chemotherapy and or radiation or none at all are given prior to stem cell transpla.

A stem cell transplant is the only treatment that can cure myelofibrosis. Myelofibrosis mf is a clonal myeloproliferative neoplasm mpn that can arise de novo or result from previous polycythemia vera or essential thrombocythemia post et mf. For myelofibrosis the procedure uses stem cells from a donor allogeneic stem cell transplant. Allogeneic stem cell transplantation is the only current treatment with the potential to cure mf but it also carries a high risk of life threatening side effects.

Bone marrow transplantation is a treatment procedure in which damaged or faulty bone marrow is replaced by healthy bone marrow from a donor. Mf is characterized by a clonal stem cell process resulting in ineffective erythropoiesis reactive fibrosis in bone marrow and extramedullary hematopoiesis in the spleen or in multiple organs 1. 2 hematopoietic stem cell transplant is the most effective cure for myelofibrosis. British journal of haematology 29 march 2012 sources.

1 recently reported a significant improvement in outcome of patients with myelofibrosis mf after allogeneic stem cell transplantation sct. This treatment has the potential to cure myelofibrosis but it also carries a high risk of life threatening side effects including a risk that the new stem cells will react against your body s healthy tissues graft versus host disease.